What is Dabigatran?
Dabigatran is an anticoagulant medication, also known as a blood thinner, used primarily to reduce the risk of stroke and blood clots in people with atrial fibrillation (a heart rhythm disorder not caused by a heart valve problem). It works by making it easier for blood to flow through veins, thereby reducing the chances of clot formation.
Dabigatran Uses
Dabigatran is prescribed for several conditions and situations:
- Prevention of stroke in patients with atrial fibrillation
- Prevention of harmful blood clots, including those in the legs (deep vein thrombosis) and lungs (pulmonary embolism)
- Treatment of blood clots in the veins of the lungs
- Prevention of blood clots after hip replacement surgery
Dabigatran Side Effects
Common Side Effects:
- Stomach cramps
- Upset stomach
- Heartburn
- Nausea
Serious Side Effects:
- Serious bleeding, characterized by:
- Unusual bleeding
- Brown urine
- Blood in vomit
- Bleeding gums
- Nosebleeds
- Joint pain
- Headache
- Weakness
- Hives
- Rash
- Itching
- Difficulty breathing
If any serious symptoms occur, seek immediate medical attention.
Precautions
Before taking Dabigatran, inform your doctor if you have allergies to it or any other medications. Discuss any medical history you have, especially if you’ve had:
- Mechanical heart valve
- Kidney disease
- Bleeding problems
- Blood disorders
- Liver disease
- Stroke
- Clotting disorders
How to Take Dabigatran
Take Dabigatran with a full glass of water. The capsules should be swallowed whole; do not crush, chew, break, or open them. The medication can be taken with or without food.
Dosage
Drug Form and Strengths:
- Dabigatran is available in 75 mg and 150 mg strengths.
Adult Dosage:
- For deep vein thrombosis (DVT): 150 mg twice daily.
- Prevention of thromboembolism in atrial fibrillation: 150 mg twice daily.
- DVT or PE after hip replacement surgery: 110 mg within 1 to 4 hours after surgery, then 220 mg once daily for 28 to 35 days.
- Reducing the risk of DVT and pulmonary embolism: 2.5 mg twice daily.
Missed Dose
If you miss a dose of Dabigatran, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose to catch up.
Overdose
Overdosing on Dabigatran can have serious consequences. If you suspect an overdose, seek immediate medical help.
Interactions
Dabigatran can interact with other medications, affecting how it works or increasing the risk of serious side effects. Some drugs that may interact with Dabigatran include mifepristone, cobicistat, cyclosporine, dronedarone, ketoconazole, and rifampin. Avoid taking aspirin, NSAIDs (e.g., ibuprofen, naproxen), or other blood-thinning medications without consulting your doctor.
Storage
Store Dabigatran at room temperature between 68ºF and 77ºF (20ºC and 25ºC), away from heat, light, and moisture. Keep it out of the reach of children.
Dabigatran vs Aspirin
| Dabigatran | Aspirin |
|---|---|
| Used to lower the risk of stroke in atrial fibrillation and prevent blood clots | Used as an anti-inflammatory drug to treat fever and inflammation |
| Treats blood clots in veins, including those in the lungs | Treats arthritis and other inflammatory conditions |
| Common side effects include upset stomach, heartburn, and nausea | Common side effects include nausea, vomiting, stomach pain, and heartburn |
Always consult your doctor before starting or stopping Dabigatran. Follow your prescribed dosage and discuss any concerns or side effects promptly with your healthcare provider. For emergencies or severe reactions, seek immediate medical attention. Carry your medications with you when traveling to manage potential emergencies effectively.
