Esomeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production. It is available in capsules, tablets, granules, and liquid (oral suspension) forms.
Prevention of gastrointestinal bleeds associated with NSAID use
Long-term treatment of pathological hypersecretory conditions, such as Zollinger-Ellison Syndrome
Side Effects of Esomeprazole
Common side effects include:
Headache
Nausea
Diarrhea
Gas
Constipation
Dry mouth
Drowsiness
Serious side effects include:
Blisters or peeling skin
Hives
Rash
Itching
Difficulty breathing or swallowing
Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
Hoarseness
Irregular, fast, or pounding heartbeat
Excessive tiredness
Dizziness
Lightheadedness
Muscle spasms, cramps, or weakness
Jitteriness
Shaking of a part of the body
Seizures
Severe diarrhea with watery stools
Stomach pain
Fever
New or worsening joint pain
Rash on cheeks or arms that are sensitive to sunlight
Decreased urination
Blood in the urine
Precautions To Follow
Inform your doctor about any allergies to Esomeprazole or related medicines.
Disclose your medical history, especially liver disease and lupus.
Seek immediate medical attention for symptoms like chest pain, difficulty swallowing, or bleeding.
Inform your doctor of all medications, including herbal products, before surgery.
Long-term use of esomeprazole may increase the risk of bone fractures, especially in older adults.
Older adults and children may be more prone to side effects.
Avoid esomeprazole during pregnancy unless advised by a doctor; its effects on breastfeeding are uncertain.
How to Use Esomeprazole
Read the Drug Guide and Patient Information Leaflet provided by your pharmacist.
Take orally, usually once daily, at least an hour before a meal, or as directed by the physician.
Follow dosage instructions carefully; do not exceed the prescribed dose or frequency.
Swallow capsules whole; do not crush or chew.
If needed, capsules can be opened and contents mixed with unheated applesauce, then consumed immediately.
Take antacids if needed, but at least 30 minutes before sucralfate if taking it.
Take it at the same time daily.
Continue treatment for the prescribed duration; consult the doctor if symptoms persist or worsen.
Interactions
Esomeprazole may interact with:
Cilostazol
Clopidogrel
Methotrexate
Rifampin
St. John’s wort
Certain drugs require stomach acid for absorption, and Esomeprazole may affect their effectiveness, including atazanavir, erlotinib, and certain antifungals.
Dosage
Esomeprazole is available in tablet, injection, and oral suspension forms, with strengths ranging from 10mg to 40mg.
Missed Dose
Take the missed dose as soon as you remember; do not double the dose.
Overdose
Seek medical help or call emergency services if an overdose is suspected.
Storage Instructions
Keep away from direct heat, moisture, and sunlight.
Keep away from children.
Esomeprazole vs Omeprazole
Esomeprazole
Omeprazole
Brand Name: Nexium
Brand Names: Prilosec, Losec
Used to treat problems with the stomach and esophagus (acid reflux, ulcers)
Used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome
Formula: C17H19N3O3S
Formula: C17H19N3O3S
Treats symptoms of GERD and other disorders with excessive stomach acid
Also used to treat damage from GERD in adults and children
