What is Imipenem?
Imipenem is a semisynthetic thienamycin with antibacterial activity against both gram-positive and gram-negative aerobic and anaerobic bacteria, including several multiresistant strains. It is commonly used in combination with cilastatin for the treatment of bacterial infections. Imipenem is known as a carbapenem-type antibiotic, which works by stopping the growth of bacteria.
Imipenem Uses
Imipenem injection is used to treat:
- Endocarditis (infection of the heart lining and valves)
- Respiratory tract infections (including pneumonia)
- Urinary tract infections
- Abdominal disorders
- Gynecological problems
- Blood infections
- Skin infections
- Bone and joint infections
Imipenem belongs to a group of antibiotics known as carbapenems and functions by killing bacteria.
Imipenem Side Effects
Common Side Effects:
- Nausea
- Vomiting
- Diarrhea
- Headache
- Redness
- Pain
- Swelling at the injection site
Serious Side Effects:
- Hives
- Itching
- Rash
- Difficulty breathing
- Blisters on the skin
- Sloughing of skin
- Seizures
If side effects persist or worsen, contact your doctor immediately.
Precautions
Before using Imipenem, talk to your doctor if you:
- Are allergic to it or any related medications
- Have a medical history of brain disorders, kidney disease, liver disease, or stomach and intestinal diseases
Avoid live bacterial vaccines (such as the typhoid vaccine) while taking this drug. The kidneys eliminate this drug, so elderly people may be more susceptible to side effects.
How to Use Imipenem
Imipenem injection comes in powder form to be mixed with liquid for intravenous (IV) or intramuscular (IM) injection.
Intravenous (IV) Use:
- Infused over 20 minutes to 1 hour every 6 to 8 hours
Intramuscular (IM) Use:
- Injected into thigh muscles every 12 hours
Treatment duration depends on the infection type.
Dosage Forms & Strengths
Imipenem:
- 250 mg to 500 mg (Powder for injection)
Dosing for Infections:
- Lower respiratory tract and gynecologic infections: 500-700 mg IV every 12 hours
- Intra-abdominal infections: 250-500 mg IV every 6 hours (severe: 500-800 mg IV every 6 hours for 4-7 days)
- Pseudomonas infections: 500 mg IV every 6 hours
- Urinary tract infections: 250-500 mg IV every 6 hours
Missed Dose
If you miss a dose, contact your doctor or pharmacist as soon as possible to reschedule. Do not double the dose.
Overdose
An overdose of this drug is unlikely to cause significant side effects. However, ingestion may require immediate medical attention.
Warnings for Serious Health Conditions
Pregnancy & Breastfeeding:
- Classified as a pregnancy category C drug.
- Use only when necessary and under doctor supervision.
- May pass into breastmilk; avoid use while breastfeeding.
Storage
Keep Imipenem at room temperature (68°F to 77°F / 20°C to 25°C) and away from heat, air, and light. Keep out of reach of children.
Imipenem vs Meropenem
| Imipenem | Meropenem |
|---|---|
| Semisynthetic thienamycin with activity against various bacteria | Intravenous β-lactam antibiotic |
| Used for treating endocarditis, respiratory, urinary tract, and abdominal infections | Used for treating bacterial skin and abdominal infections, meningitis in adults |
| Common Side Effects: | Common Side Effects: |
| Nausea, Vomiting, Diarrhea, Headache | Headache, Diarrhea, Constipation, Nausea, Vomiting, Pain |
