Levodopa (L-dopa) is the most effective and widely used drug for Parkinson’s disease.
Carbidopa is an inhibitor of L-amino acid decarboxylase, the plasma enzyme that metabolises levodopa peripherally. It is commonly combined with levodopa.
Uses of Levodopa
The combination medication is used in the treatment of Parkinson’s disease and its symptoms, such as:
Shakiness
Stiffness
Difficulty moving
It increases dopamine levels in the brain, compensating for dopamine deficiency, a critical factor in Parkinson’s disease.
Side Effects of Levodopa
Dizziness
Loss of appetite
Diarrhea
Dry mouth
Mouth and throat pain
Constipation
Change in sense of taste
Confusion
Nervousness
Nightmares
Difficulty falling asleep
Headache
Increased sweating
Chest pain
Depression
Hallucinating
Hoarseness
Difficulty swallowing
Difficulty in breathing
Hives
Weakness
Numbness
Red blood in stools
Fever
Precautions Before Taking Medicine
Before taking this medication, tell your doctor or pharmacist about your medical history, especially if you have:
Allergies
Liver disease
Glaucoma
Breathing problems
Heart disease
Kidney disease
Stomach/intestinal ulcer
Mental/mood disorders
Blood disorders
Seizures or sleep disorders
Use levodopa during pregnancy and breastfeeding only when necessary and under a doctor’s prescription.
Avoid alcohol consumption.
How to use Levodopa?
Interactions
Antipsychotic drugs (such as chlorpromazine, haloperidol, and thioridazine), as well as certain drugs used to treat high blood pressure, may interact with this medication.
Using MAO inhibitors in conjunction with this medication may result in a serious drug interaction. Most MAO inhibitors should also be avoided for two weeks before starting this medication. Certain MAO inhibitors may be used with caution under the supervision of your doctor. Consult your doctor.
This medication may cause false test results in certain laboratory tests (including urine catecholamine/glucose/ketone tests).
Overdose
If someone has taken an overdose of this medicine and has serious symptoms such as trouble breathing, seek medical advice immediately.
Never take more doses than what is prescribed to you by your doctor.
Missed Dose
It is necessary to take each dose of this medication on time.
If you forget a dose, contact your doctor as soon as possible to arrange for a new dosing schedule.
Do not double the dose.
Storage Instructions
The medicine must not come in contact with heat, air, or light, which may damage your medicines.
The medicine must be kept in a safe place and far away from children’s reach.
Levodopa vs Carbidopa
Levodopa
Carbidopa
This belongs to a class of drugs known as central nervous system agents.
Carbidopa is from a class of drugs known as decarboxylase inhibitors.
This is used in the treatment of Parkinson’s disease symptoms (such as shakiness, stiffness, difficulty moving).
Carbidopa is a medication used to treat Parkinson’s disease that inhibits the peripheral metabolism of levodopa.
It works in the brain by being converted to dopamine.
It prevents the breakdown of levodopa before reaching the brain.
