What is Hydralazine?
Hydralazine, also known as Apresoline, is a medication used to treatΒ high blood pressureΒ and heart failure, including high blood pressure during pregnancy. Although the precise mechanism of hydralazine is unknown, its most significant effects are on the cardiovascular system.
Hydralazine Uses
Hydralazine is used to treat high blood pressure, either alone or in combination with other medications. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is classified as a vasodilator, working by relaxing blood vessels to allow blood to flow more easily through the body.
How to Use Hydralazine?
Take this medication orally, with or without food, 2 to 4 times per day, or as directed by your doctor. The dosage depends on your medical condition and response to treatment.
- Begin with a low dose and gradually increase it as advised.
- Take it regularly to get the most benefit.
- Continue taking even if you feel fine; high blood pressure often has no symptoms.
- Do not stop suddenly without consulting your doctor; your dose may need to be gradually reduced.
- Notify your doctor if your condition worsens (e.g., increased blood pressure readings).
Hydralazine Side Effects
Serious side effects may include:
- Flushing
- Headache
- Upset stomach
- Vomiting
- Loss of appetite
- Diarrhea
- Constipation
- Eye tearing
- Stuffy nose
- Rash
- Fainting
- Joint or muscle pain
- Fever
- Rapid heartbeat
- Chest pain
- Swollen ankles or feet
- Numbing or tingling in hands or feet
Precautions
Before taking Hydralazine, inform your doctor if you have any allergies or medical history of:
- Heart problems (e.g., coronary artery disease, recent heart attack, rheumatic heart disease of the mitral valve)
- Blood vessel problems
- Previous stroke
- Kidney problems
This medication may cause dizziness; avoid activities requiring alertness until you are sure you can perform them safely. Limit alcohol intake. Use this medication during pregnancy only if prescribed by a doctor. It is excreted in breast milk but is unlikely to harm a nursing infant.Β Consult your doctor before breastfeeding.
Interactions
Certain products may interact with this medication, such as:
- MAO inhibitors (e.g., isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine)
- Products that may increase heart rate, blood pressure, or worsen heart failure (e.g., cough and cold remedies, diet supplements, NSAIDs like ibuprofen/naproxen)
Missed Dose
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose. Do not take a double dose to make up for a missed one.
Overdose
An overdose can be accidental. If more than the prescribed amount is taken, it can harm your bodyβs functions. Seek immediate medical attention if an overdose occurs.
Storage
Store the medicine away from heat, air, and light to prevent harmful effects. Keep it in a safe place out of childrenβs reach.
Hydralazine vs Nitroglycerin:
| Hydralazine | Nitroglycerin |
|---|---|
| Also known as Apresoline, used to treat high blood pressure andΒ heart failure. | Also known as glyceryl trinitrate (GTN), used to treat and prevent heart failure, hypertension, anal fissures, painful periods, and chest pain caused by decreased blood flow to the heart or recreational cocaine use. |
| It works by relaxing blood vessels, allowing blood to flow more easily through the body. | Works by relaxing your body’s smooth muscle and blood vessels. |
