Selegiline is a monoamine oxidase type B (MAO-B) inhibitor used to manage symptoms of Parkinson’s disease. It helps by preventing the breakdown of dopamine in the brain, which is crucial for controlling movement.
Selegiline Uses
Parkinson’s Disease : It is prescribed to alleviate movement disorders associated with Parkinson’s disease. While it doesn’t cure Parkinson’s, it can improve symptoms such as tremors, muscle weakness, and fluctuations in movement control (“on-off” phenomena). It is often used in combination with other Parkinson’s medications like carbidopa-levodopa.
Side Effects
Common:
Dizziness
Lightheadedness
Fainting
Dry mouth
Nausea
Vomiting
Stomach pain
Difficulty swallowing
Heartburn
Gas
Constipation
Sleepiness
Depression
Muscle pain
Weakness
Rash
Serious (Seek Medical Attention):
Severe headache
Chest pain
Fast or irregular heartbeat
Sweating
Nausea and vomiting
Hallucinations
Hypertension (high blood pressure)
Urinary retention
Precautions
Inform your doctor if you are allergic to selegiline or any related medications.
Discuss any medical history, especially adrenal gland tumors, cerebrovascular disease, heart problems, bleeding disorders, headaches, or peptic ulcers.
Avoid using selegiline with certain medications and substances due to potential interactions.
How to Take Selegiline
Oral Tablet : Usually taken twice daily with breakfast and lunch.
Orally Disintegrating Tablet : Taken once daily before breakfast. Place the tablet on the tongue and allow it to dissolve without swallowing. Avoid eating or drinking for 5 minutes before and after taking the tablet.
Dosage
Oral Tablet : Typically started at 5 mg twice daily, with a maximum daily dose of 10 mg.
Orally Disintegrating Tablet : Initiated at 1.25 mg daily for at least 6 weeks, with potential to increase to 2.5 mg daily if needed.
Missed Dose
Missing a dose generally has no significant effects, but follow your doctor’s instructions. Do not double up on doses.
Overdose
Accidental overdose can be serious. Seek medical attention immediately if you suspect an overdose.
Interactions
Selegiline can interact with various medications, including antidepressants, other MAO inhibitors, appetite suppressants, ADHD medications, and others. Always inform your doctor about all medications you are taking.
Storage
Store selegiline at room temperature, away from heat, light, and moisture. Keep it out of reach of children.
Selegiline vs Adderall
Selegiline :
Used for Parkinson’s disease symptoms.
MAO-B inhibitor.
Adderall :
Combination of dextroamphetamine and amphetamine.
Used for ADHD and narcolepsy.
Side effects differ, including palpitations, tachycardia, euphoria, blurred vision, and dry mouth.
